Cobi J Heijnen Selected Research

G-protein-coupled receptor kinase 6

5/2012	G protein-coupled receptor kinase 6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting phosphatidylinositol 3-kinase and inhibiting p38 signaling.
1/2009	G protein-coupled receptor kinase 6 controls post-inflammatory visceral hyperalgesia.
6/2007	G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice.
12/2003	Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6.

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Cobi J Heijnen Research Topics

Disease

35	Inflammation (Inflammations) 01/2022 - 04/2003
27	Hyperalgesia 01/2022 - 03/2007
24	Neoplasms (Cancer) 01/2022 - 09/2002
23	Pain (Aches) 01/2022 - 03/2007
19	Peripheral Nervous System Diseases (PNS Diseases) 01/2022 - 01/2014
19	Hypoxia (Hypoxemia) 11/2017 - 04/2004
17	Ischemia 11/2017 - 04/2004
14	Neuralgia (Stump Neuralgia) 01/2022 - 06/2012
14	Brain Injuries (Brain Injury) 01/2017 - 10/2005
12	Chronic Pain 01/2022 - 08/2011
11	Fatigue 10/2018 - 02/2007
10	Cognitive Dysfunction 01/2022 - 01/2016
9	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 11/2015
7	Chemotherapy-Related Cognitive Impairment 01/2022 - 01/2016
7	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2015 - 01/2011
6	Hypersensitivity (Allergy) 01/2022 - 12/2006
6	Neuroinflammatory Diseases 10/2020 - 10/2005
6	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 05/2010 - 04/2004
5	Wounds and Injuries (Trauma) 05/2013 - 09/2008
5	Lung Diseases (Lung Disease) 11/2008 - 12/2006
4	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2013 - 04/2003
4	Pneumonia (Pneumonitis) 12/2010 - 06/2003
3	Hypesthesia (Numbness) 01/2019 - 10/2016
3	Insulin Resistance 01/2018 - 11/2009
3	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 01/2018 - 01/2010
3	Stroke (Strokes) 01/2017 - 04/2012
3	Gliosis 01/2017 - 11/2014
3	Infections 01/2016 - 01/2006
3	Ventilator-Induced Lung Injury 01/2013 - 06/2003
3	Birth Weight (Birth Weights) 11/2009 - 12/2006
3	Colitis 01/2009 - 06/2007
2	Breast Neoplasms (Breast Cancer) 01/2022 - 01/2017
2	Rheumatoid Arthritis 01/2021 - 03/2005
2	Body Weight (Weight, Body) 01/2018 - 07/2015
2	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2017 - 05/2013

Drug/Important Bio-Agent (IBA)

22	CytokinesIBA 01/2020 - 06/2003
20	Cisplatin (Platino)FDA LinkGeneric 01/2022 - 01/2014
14	Proteins (Proteins, Gene)FDA Link 10/2020 - 04/2003
12	Hydrocortisone (Cortisol)FDA LinkGeneric 12/2013 - 12/2006
11	Interleukin-10 (Interleukin 10)IBA 01/2022 - 01/2008
9	Phosphotransferases (Kinase)IBA 10/2021 - 08/2011
9	Dexamethasone (Maxidex)FDA LinkGeneric 07/2013 - 12/2006
8	Paclitaxel (Taxol)FDA LinkGeneric 01/2021 - 01/2014
8	GlucocorticoidsIBA 03/2015 - 01/2007
8	ChemokinesIBA 01/2014 - 05/2004
7	Pharmaceutical PreparationsIBA 01/2022 - 01/2010
7	G-Protein-Coupled Receptor Kinase 2IBA 01/2018 - 04/2004
6	InterleukinsIBA 12/2018 - 02/2008
6	Biomarkers (Surrogate Marker)IBA 10/2018 - 01/2011
5	Neuroprotective AgentsIBA 01/2017 - 01/2005
5	Messenger RNA (mRNA)IBA 01/2016 - 06/2003
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2012 - 10/2009
5	NF-kappa B (NF-kB)IBA 05/2010 - 02/2006
5	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2009 - 04/2003
4	Histone Deacetylase 6IBA 01/2022 - 10/2018
4	Biological ProductsIBA 11/2021 - 02/2012
4	Interleukin-6 (Interleukin 6)IBA 07/2018 - 04/2002
4	erythromycin propionate-N-acetylcysteinateIBA 05/2018 - 09/2010
4	CarrageenanIBA 05/2014 - 02/2010
4	Erythropoietin FDA Link 01/2013 - 11/2008
4	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 11/2012 - 11/2009
4	G-protein-coupled receptor kinase 6IBA 05/2012 - 12/2003
3	PlatinumIBA 01/2022 - 11/2015
3	Metformin (Glucophage)FDA LinkGeneric 08/2019 - 01/2014
3	3- (5- tert- butylisoxazol- 3- yl)- 2- ((3- chlorophenyl)hydrazono)- 3- oxopropionitrileIBA 05/2018 - 03/2016
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 08/2002
3	pifithrinIBA 01/2017 - 11/2015
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 03/2014 - 07/2010
3	G-Protein-Coupled Receptor KinasesIBA 06/2012 - 08/2011
3	salicylhydroxamic acid (SHAM)IBA 07/2010 - 10/2008
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 04/2009 - 10/2005
3	Drinking WaterIBA 01/2009 - 06/2007
3	Dextrans (Dextran)FDA Link 01/2009 - 06/2007
3	Neurotransmitter Agents (Neurotransmitter)IBA 03/2008 - 04/2005
3	2-iminobiotinIBA 02/2007 - 01/2005
2	Clodronic Acid (Clodronate)IBA 01/2022 - 01/2016
2	Liposomes (Liposome)IBA 01/2022 - 01/2016
2	C-Reactive ProteinIBA 01/2022 - 12/2013
2	Interleukin-10 ReceptorsIBA 01/2022 - 10/2020
2	AutoantigensIBA 01/2021 - 11/2002
2	ricolinostatIBA 12/2019 - 01/2017
2	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 01/2019 - 05/2015
2	Tryptophan (L-Tryptophan)FDA Link 12/2018 - 05/2015
2	KynurenineIBA 12/2018 - 11/2017
2	Dinoprostone (PGE2)FDA Link 01/2018 - 09/2010
2	EnzymesIBA 11/2017 - 05/2015
2	Interleukin-1 (Interleukin 1)IBA 11/2017 - 09/2010
2	Myelin Basic ProteinIBA 01/2017 - 01/2011
2	Hormones (Hormone)IBA 01/2017 - 02/2012
2	LipopolysaccharidesIBA 01/2016 - 06/2003

Therapy/Procedure

29	Drug Therapy (Chemotherapy) 01/2022 - 01/2014
21	Therapeutics 01/2021 - 01/2006
7	Intranasal Administration 01/2022 - 05/2013
5	Artificial Respiration (Mechanical Ventilation) 12/2010 - 05/2003
3	Aftercare (After-Treatment) 01/2022 - 01/2017
3	Transplantation 11/2017 - 04/2012
3	Mechanical Ventilators (Ventilator) 01/2013 - 06/2003
2	Remission Induction 07/2018 - 01/2018
2	Oral Administration 01/2018 - 11/2002
2	Radiotherapy 01/2017 - 01/2016